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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAPK3
All Species:
17.88
Human Site:
T66
Identified Species:
28.1
UniProt:
P27361
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P27361
NP_001035145.1
379
43136
T66
A
Y
D
H
V
R
K
T
R
V
A
I
K
K
I
Chimpanzee
Pan troglodytes
XP_510921
379
43006
T66
A
Y
D
H
V
R
K
T
R
V
A
I
K
K
I
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_854045
378
42847
V65
A
D
D
H
V
R
K
V
R
V
A
I
K
K
I
Cat
Felis silvestris
Mouse
Mus musculus
Q63844
380
43048
T67
A
Y
D
H
V
R
K
T
R
V
A
I
K
K
I
Rat
Rattus norvegicus
P21708
380
43062
T67
A
Y
D
H
V
R
K
T
R
V
A
I
K
K
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989481
368
41924
V57
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
Frog
Xenopus laevis
P26696
361
41238
V52
A
H
D
N
V
N
K
V
R
V
A
I
K
K
I
Zebra Danio
Brachydanio rerio
NP_958915
392
44081
I80
A
F
D
N
V
N
K
I
R
V
A
I
K
K
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P40417
426
49103
Q112
A
D
D
T
L
T
N
Q
R
V
A
I
K
K
I
Honey Bee
Apis mellifera
XP_393029
371
42705
T51
A
Y
D
N
V
T
K
T
K
V
A
I
K
K
I
Nematode Worm
Caenorhab. elegans
P39745
444
50644
D120
A
L
D
T
I
T
R
D
R
V
A
I
K
K
I
Sea Urchin
Strong. purpuratus
NP_999813
369
42176
G55
A
V
D
T
R
H
G
G
K
V
A
I
K
K
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39024
376
42833
E67
A
T
N
S
E
T
G
E
E
V
A
I
K
K
I
Baker's Yeast
Sacchar. cerevisiae
P16892
353
40754
F47
A
I
K
K
I
E
P
F
D
K
P
L
F
A
L
Red Bread Mold
Neurospora crassa
Q96TL5
358
41225
Q44
A
K
D
Q
L
T
N
Q
N
V
A
I
K
K
I
Conservation
Percent
Protein Identity:
100
95.7
N.A.
96.3
N.A.
96.8
97.1
N.A.
N.A.
83.1
82.3
82.4
N.A.
68.5
78.3
62.1
77.5
Protein Similarity:
100
96.8
N.A.
97.6
N.A.
97.1
97.3
N.A.
N.A.
88.3
87.5
87.2
N.A.
75.5
84.4
72.5
84.4
P-Site Identity:
100
100
N.A.
86.6
N.A.
100
100
N.A.
N.A.
80
73.3
73.3
N.A.
60
80
60
53.3
P-Site Similarity:
100
100
N.A.
86.6
N.A.
100
100
N.A.
N.A.
86.6
86.6
86.6
N.A.
66.6
93.3
73.3
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
48.5
47.2
46.1
Protein Similarity:
N.A.
N.A.
N.A.
66.7
63.8
62.5
P-Site Identity:
N.A.
N.A.
N.A.
46.6
6.6
53.3
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
26.6
60
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
100
0
0
0
0
0
0
0
0
0
94
0
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
14
87
0
0
0
0
7
7
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
7
7
0
7
7
0
0
0
0
0
0
% E
% Phe:
0
7
0
0
0
0
0
7
0
0
0
0
7
0
0
% F
% Gly:
0
0
0
0
0
0
14
7
0
0
0
0
0
0
0
% G
% His:
0
7
0
34
0
7
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
14
0
0
7
0
0
0
94
0
0
94
% I
% Lys:
0
7
7
7
0
0
60
0
14
7
0
0
94
94
0
% K
% Leu:
0
7
0
0
14
0
0
0
0
0
0
7
0
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
27
0
20
14
0
7
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
7
0
0
0
7
0
0
0
0
% P
% Gln:
0
0
0
7
0
0
0
14
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
7
34
7
0
67
0
0
0
0
0
0
% R
% Ser:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
7
0
20
0
34
0
34
0
0
0
0
0
0
0
% T
% Val:
0
7
0
0
60
0
0
20
0
94
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
40
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _